Effects of oral administration of orodispersible levo-carnosine on quality of life and exercise performance in patients with chronic heart failure.

@article{Lombardi2015EffectsOO,
  title={Effects of oral administration of orodispersible levo-carnosine on quality of life and exercise performance in patients with chronic heart failure.},
  author={Carlo Mario Lombardi and Valentina Carubelli and Valentina Lazzarini and Enrico Vizzardi and Tania Bordonali and Camilla Ciccarese and Anna Isotta Castrini and Alessandra Dei Cas and Savina Nodari and Marco Metra},
  journal={Nutrition},
  year={2015},
  volume={31 1},
  pages={
          72-8
        }
}

Figures and Tables from this paper

Beneficial effects of carnosine and carnosine plus vitamin E treatments on doxorubicin-induced oxidative stress and cardiac, hepatic, and renal toxicity in rats

The results may indicate that CAR alone, especially in combination with Vit E, protect against DOX-induced toxicity in heart, liver, and kidney tissues of rats.

Does supplementation with carnosine improve cardiometabolic health and cognitive function in patients with pre-diabetes and type 2 diabetes? study protocol for a randomised, double-blind, placebo-controlled trial

Whether supplementation with carnosine improves cardiometabolic health and cognitive function in patients with pre-diabetes and T2DM is investigated.

Effects of 3-months carnosine supplementation on insulin resistance and glucose intolerance in overweight and obese sedentary individuals: Pilot Clinical Trial

These first pilot-human interventional metabolic data suggest that carnosine may improve glucose tolerance and impede insulin resistance development and thus could contribute to the prevention of type 2 diabetes.

Use of carnosine in the prevention of cardiometabolic risk factors in overweight and obese individuals: study protocol for a randomised, double-blind placebo-controlled trial

If carnosine supplementation improves obesity, insulin sensitivity, insulin secretion, cardiovascular risk factors including arterial stiffness and endothelial function, and other risk factors related to diabetes and cardiovascular disease in the overweight and obese population is established.

Carnosine and histidine-containing dipeptides improve dyslipidemia: a systematic review and meta-analysis of randomized controlled trials.

Carnosine and other HCDs may have a role in improving lipid profiles and larger studies with sufficient follow-up are necessary to confirm these findings and explore the use of H CDs in the prevention of cardiovascular diseases.

Muscle Carnosine Is Associated with Cardiometabolic Risk Factors in Humans

Higher carnosine content in human skeletal muscle is positively associated with insulin resistance and fasting metabolic preference for glucose, and negatively associated with HDL-cholesterol and basal energy expenditure.

Carnosine, Small but Mighty—Prospect of Use as Functional Ingredient for Functional Food Formulation

The present review aimed to provide recent knowledge on carnosine properties and distribution, its metabolism (synthesis and degradation), and analytical methods for Carnosine determination, since one of the difficulties is the measurement of carnosines concentration in human samples.
...

References

SHOWING 1-10 OF 75 REFERENCES

Acute and Chronic Effects of Propionyl-L-Carnitine on the Hemodynamics, Exercise Capacity, and Hormones in Patients with Congestive Heart Failure

It is concluded that propionyl-L-carnitine increases exercise capacity and reduces ventricular size in patients with congestive heart failure and the drug has no significant effects on hemodynamics or neurohormone levels.

The effect of micronutrient supplementation on quality-of-life and left ventricular function in elderly patients with chronic heart failure.

Long-term multiple micronutrient supplementation can improve LV volumes and LVEF and QoL scores in elderly patients with heart failure due to LV systolic dysfunction.

Effects of Oral Amino Acid Supplements on Functional Capacity in Patients with Chronic Heart Failure

In this study, AAs supplementation in patients with chronic stable HF improved exercise tolerance but did not change quality of life.

Effect of L-arginine or L-citrulline oral supplementation on blood pressure and right ventricular function in heart failure patients with preserved ejection fraction.

Administration of L-arginine and citrulline to patients with HFpEF improved right ventricular function by increasingright ventricular ejection fraction, and probably decreasing systolic pulmonary artery pressure.

Micronutrient deficiencies an unmet need in heart failure.

Effects of Beta-Alanine on Muscle Carnosine and Exercise Performance:A Review of the Current Literature

The theoretical rationale and potential ergogenic value of β-ALA supplementation with or without creatine monohydrate is overviewed as well as future research recommendations are provided.

Amino acids and derivatives, a new treatment of chronic heart failure?

Recent data suggest that a multi-nutritional approach, including also antioxidants, vitamins, and metals, may be more effective in patients with HF, and larger trials are needed to ascertain safety, efficacy, and impact on prognosis of such an approach in HF.

Effect of beta-alanine supplementation on muscle carnosine concentrations and exercise performance

This paper reviews the available evidence relating to the effects of β-alanine supplementation on muscle carnosine synthesis and the subsequent effects on exercise performance and proposes a method of increasing intracellular buffering capacity during exercise, which could provide a means of increasing high-intensity exercise capacity and performance.

Ergogenic Effects of β-Alanine and Carnosine: Proposed Future Research to Quantify Their Efficacy

This review focuses on their roles as ergogenic aids to exercise performance and suggests how to best quantify the former’s merits as a buffer and blood lactate kinetics, whereby the concentration of the metabolite is measured as it enters and leaves the vasculature over time, affords the best opportunity to assess the merits of β-alanine supplementation”s ergogenic effect.

Oral amino acid supplements improve exercise capacities in elderly patients with chronic heart failure.

...