Effects of oral administration of a synthetic fragment of human growth hormone on lipid metabolism.

@article{Heffernan2000EffectsOO,
  title={Effects of oral administration of a synthetic fragment of human growth hormone on lipid metabolism.},
  author={Mark Heffernan and W. J. Jiang and A. W. Thorburn and Frank M. Ng},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2000},
  volume={279 3},
  pages={
          E501-7
        }
}
  • M. HeffernanW. J. Jiang F. Ng
  • Published 1 September 2000
  • Biology, Medicine
  • American journal of physiology. Endocrinology and metabolism
A small synthetic peptide sequence of human growth hormone (hGH), AOD-9401, has lipolytic and antilipogenic activity similar to that of the intact hormone. Here we report its effect on lipid metabolism in rodent models of obesity and in human adipose tissue to assess its potential as a pharmacological agent for the treatment of human obesity. C57BL/6J (ob/ob) mice were orally treated with either saline (n = 8) or AOD-9401 (n = 10) for 30 days. From day 16 onward, body weight gain in AOD-9401… 

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Safety and Metabolism of AOD9604, a Novel Nutraceutical Ingredient for Improved Metabolic Health

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