Effects of oral S-adenosyl-L-methionine on hepatic glutathione in patients with liver disease.

@article{Vendemiale1989EffectsOO,
  title={Effects of oral S-adenosyl-L-methionine on hepatic glutathione in patients with liver disease.},
  author={Gianluigi Vendemiale and Emanuele Altomare and T Trizio and C Le Grazie and C di Padova and Maria T Salerno and V K Carrieri and O. Albano},
  journal={Scandinavian journal of gastroenterology},
  year={1989},
  volume={24 4},
  pages={407-15}
}
S-Adenosyl-L-methionine (SAMe) is a physiologic precursor of thiols and sulfurated compounds, which are known to be decreased in patients with liver disease. The effect of its administration on the hepatic glutathione content of liver patients was investigated. Four groups of subjects were selected: a) 9 patients with alcoholic liver disease treated with SAMe (1.2 g/day orally for 6 months); b) 7 patients with non-alcoholic liver disease treated as above; c) 8 placebo-treated patients with… CONTINUE READING
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