Effects of oral AVP receptor antagonists OPC-21268 and OPC-31260 on congestive heart failure in conscious dogs.

Abstract

Rapid right ventricular pacing could induce congestive heart failure in conscious dogs with significant increase in plasma concentration of arginine vasopressin (AVP) (from 1.2 +/- 0.2 to 3.4 +/- 0.6 pg/ml). In this experimental model of heart failure, oral administration of the selective AVP V1 receptor antagonist OPC-21268 significantly increased cardiac… (More)

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Cite this paper

@article{Naitoh1994EffectsOO, title={Effects of oral AVP receptor antagonists OPC-21268 and OPC-31260 on congestive heart failure in conscious dogs.}, author={Munetaka Naitoh and H. Suzuki and M. Murakami and Alvin M. Matsumoto and K. Arakawa and Akitami Ichihara and H. Nakamoto and Kazuyuki Oka and Yoriko Yamamura and Takayuki Saruta}, journal={The American journal of physiology}, year={1994}, volume={267 6 Pt 2}, pages={H2245-54} }