Effects of oral 5-hydroxy-tryptophan on energy intake and macronutrient selection in non-insulin dependent diabetic patients

@article{Cangiano1998EffectsOO,
  title={Effects of oral 5-hydroxy-tryptophan on energy intake and macronutrient selection in non-insulin dependent diabetic patients},
  author={Carlo Cangiano and Alessandro Laviano and Maria Del Ben and Isabella Preziosa and Francesco Angelico and Antonia Cascino and Filippo Rossi-Fanelli},
  journal={International Journal of Obesity},
  year={1998},
  volume={22},
  pages={648-654}
}
OBJECTIVE: In obese patients, brain serotonergic stimulation via orally administered 5-hydroxy-tryptophan (5-HTP), the precursor of serotonin, causes decreased carbohydrate intake and weight loss. Since diabetes mellitus is associated with depressed brain serotonin, hyperphagia and carbohydrate craving, we hypothesized that in diabetic patients, orally administered 5-HTP stimulates brain serotonergic activity and thus normalizes eating behaviour. To test this hypothesis, we investigated whether… CONTINUE READING