Effects of ooplasm transfer on paternal genome function in mice.

@article{Liang2009EffectsOO,
  title={Effects of ooplasm transfer on paternal genome function in mice.},
  author={Cheng-Guang Liang and Zhiming Han and Yong Cheng and Zhisheng Zhong and Keith E Latham},
  journal={Human reproduction},
  year={2009},
  volume={24 11},
  pages={
          2718-28
        }
}
BACKGROUND The ooplasm plays a central role in forming the paternal pronucleus, and subsequently in regulating the expression of paternally inherited chromosomes. Previous studies in mice have revealed genetic differences in paternal genome processing by ooplasm of different genotypes. Ooplasm donation coupled to intracytoplasmic sperm injection (ICSI) has been used in human assisted reproductive technology (ART). This procedure exposes the developing paternal pronucleus to 'foreign' ooplasm… CONTINUE READING
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