Effects of one-year cadmium exposure on livers and kidneys and their relation to glutathione levels.

@article{Kamiyama1995EffectsOO,
  title={Effects of one-year cadmium exposure on livers and kidneys and their relation to glutathione levels.},
  author={Tsutomu Kamiyama and Hiroshi Miyakawa and Jian Li and Takashi Akiba and Jing Liu and Fumiaki Marumo and Chu Sato},
  journal={Research communications in molecular pathology and pharmacology},
  year={1995},
  volume={88 2},
  pages={177-86}
}
To study the effects of a long-term cadmium exposure on livers and kidneys, rats were administered cadmium chloride (0.228 mg Cd/kg, 3 days/week ip), for one year. Significant accumulation of cadmium was observed in livers (183 +/- 40 micrograms/g liver) and kidneys (92 +/- 17 micrograms/g kidney). Serum urea nitrogen and creatinine levels were significantly elevated in the cadmium-treated rats, while liver function tests were minimally affected. Histological observations showed interstitial… CONTINUE READING
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