Effects of oncostatin M on secretion of vascular endothelial growth factor and reconstruction of liver-like structure by fetal liver cells in monolayer and three-dimensional cultures.

@article{Ehashi2007EffectsOO,
  title={Effects of oncostatin M on secretion of vascular endothelial growth factor and reconstruction of liver-like structure by fetal liver cells in monolayer and three-dimensional cultures.},
  author={Tomo Ehashi and Toshie Koyama and K. Ookawa and Norio Ohshima and Hirotoshi Miyoshi},
  journal={Journal of biomedical materials research. Part A},
  year={2007},
  volume={82 1},
  pages={73-9}
}
Vascular endothelial growth factor (VEGF) is crucial for the development and regeneration of the liver. However, there have been no reports about VEGF secretion by cultured fetal liver cells (FLCs). In the present study, the effects of oncostatin M (OSM), which strongly stimulates the growth and albumin secretion of FLCs, on VEGF secretion and morphological changes of long-term cultured FLCs were investigated under three-dimensional (3-D) and monolayer conditions. The cultured FLCs proliferated… CONTINUE READING