Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

@article{Taipale2000EffectsOO,
  title={Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine},
  author={Jussi Taipale and James K Chen and Michael K. Cooper and Baolin Wang and Randall K. Mann and Ljiljana Milenkovic and Matthew P Scott and Philip A Beachy},
  journal={Nature},
  year={2000},
  volume={406},
  pages={1005-1009}
}
Basal cell carcinoma, medulloblastoma, rhabdomyosarcoma and other human tumours are associated with mutations that activate the proto-oncogene Smoothened (SMO) or that inactivate the tumour suppressor Patched (PTCH). Smoothened and Patched mediate the cellular response to the Hedgehog (Hh) secreted protein signal, and oncogenic mutations affecting these proteins cause excess activity of the Hh response pathway. Here we show that the plant-derived teratogen cyclopamine, which inhibits the Hh… CONTINUE READING
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