Effects of omega-3 and -6 fatty acids on Mycobacterium tuberculosis in macrophages and in mice.

@article{Jordao2008EffectsOO,
  title={Effects of omega-3 and -6 fatty acids on Mycobacterium tuberculosis in macrophages and in mice.},
  author={Luisa Jordao and Andreas 4 Lengeling and Yann Bordat and Fr{\'e}d{\'e}ric Boudou and B. Gicquel and Olivier Neyrolles and Pablo D Becker and Carlos Alberto Guzm{\'a}n and Gareth Griffiths and Elsa Anes},
  journal={Microbes and infection},
  year={2008},
  volume={10 12-13},
  pages={1379-86}
}
We recently showed that treatment of macrophages prior to Mycobacterium tuberculosis infection with the pro-inflammatory omega-6 lipid, arachidonic acid (AA) enhanced bacterial killing whereas the anti-inflammatory, omega-3 lipid eicosapentaenoic acid (EPA) stimulated bacterial growth. Here we tested if these effects were depending on when lipids were added to macrophages: before or during Mycobacterium smegmatis or M. tuberculosis infection. Collectively, our data suggested that a high omega-6… CONTINUE READING
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