Effects of oligomycin and acidosis on rates of ATP depletion in ischemic heart muscle.

@article{Rouslin1986EffectsOO,
  title={Effects of oligomycin and acidosis on rates of ATP depletion in ischemic heart muscle.},
  author={W Rouslin and Jeryl L Erickson and R. John Solaro},
  journal={The American journal of physiology},
  year={1986},
  volume={250 3 Pt 2},
  pages={H503-8}
}
The perfusion of canine cardiac muscle with 10 microM oligomycin produced a nearly 90% slowing of the net rate of tissue ATP depletion from 0.200 to 0.025 mumol X min-1 X g wet wt-1 of tissue during a subsequent myocardial autolytic interval during which tissue pH was held constant. Moreover, lowering the tissue pH during the autolytic process by 0.6 unit from approximately 6.8 to approximately 6.2 produced a nearly 60% slowing of the net rate of tissue ATP depletion from 0.200 to 0.087 mumol X… CONTINUE READING
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