Effects of oleamide on choline acetyltransferase and cognitive activities.

  title={Effects of oleamide on choline acetyltransferase and cognitive activities.},
  author={H J Heo and Y. Park and Young-Min Suh and Soo-Jung Choi and Mi-Jeong Kim and Hong-Yon Cho and Yun-Jeong Chang and Bumshik Hong and H Kim and Eunki Kim and C -K Kim and Byung-Gee Kim and D B Shin},
  journal={Bioscience, biotechnology, and biochemistry},
  volume={67 6},
We screened 50 Korean traditional natural plants to measure the activation effect on choline acetyltransferase and attenuation of scopolamine-induced amnesia. The methanolic extracts from Zizyphus jujuba among the tested 50 plants, showed the highest activatory effect (34.1%) on choline acetyltransferase in vitro. By sequential fractionation of Zizyphus jujuba, the active component was finally identified as cis-9-octadecenoamide (oleamide). After isolation, oleamide showed a 65% activation… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 25 extracted citations


Publications referenced by this paper.
Showing 1-10 of 23 references

EŠect of oleamide on sleep and its relationship to blood pressure, body temperature and locomotor activity in rats

  • S. Resendiz-Huitron, L. Gombart, B. F. Cravatt, S. J. Henriksen
  • Exp. Neurol.,
  • 2001

Current concepts in the pathogenesis of Alzheimer's disease

  • D. B. Carr, A. Goate, J. C. Morris
  • Am. J. Med., 103,
  • 1997

Similar Papers

Loading similar papers…