Effects of old age on human skeletal muscle energetics during fatiguing contractions with and without blood flow.

@article{Lanza2007EffectsOO,
  title={Effects of old age on human skeletal muscle energetics during fatiguing contractions with and without blood flow.},
  author={Ian R Lanza and Ryan Godsk Larsen and Jane A. Kent-Braun},
  journal={The Journal of physiology},
  year={2007},
  volume={583 Pt 3},
  pages={1093-105}
}
We recently reported lower glycolytic flux (ATP(GLY)) and increased reliance on oxidative ATP synthesis (ATP(OX)) in contracting muscle of older compared to young humans. To further investigate this age-related difference in the pathways of ATP synthesis, we used magnetic resonance spectroscopy to determine the rates of ATP(OX), ATP(GLY) and net phosphocreatine hydrolysis in vivo during maximal muscle contractions under free-flow (FF) and ischaemic (ISC) conditions in the ankle dorsiflexors of… CONTINUE READING

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