Effects of olanzapine and clozapine upon pulse rate variability.

  title={Effects of olanzapine and clozapine upon pulse rate variability.},
  author={Michael Mueck-Weymann and Thomas Rechlin and Franz Ehrengut and Robert Rauh and Jens Acker and Ralf Dittmann and Joerg Czekalla and Peter Joraschky and Dominique Musselman},
  journal={Depression and anxiety},
  volume={16 3},
Based upon their in vitro receptor binding profiles, the atypical antipsychotics clozapine and olanzapine exhibit cholinergic receptor binding of similar potency. Data comparing the in vivo anticholinergic effects, however, of these neuroleptics upon neurocardiac control are sparse. The goal of this study was to compare the in vivo effects of clozapine and olanzapine upon neurocardiac control by assessment of the pulse rate variability (PRV) in schizophrenic patients and healthy controls… CONTINUE READING


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