Effects of oestrogen on long noncoding RNA expression in oestrogen receptor alpha-positive ovarian cancer cells

@article{Qiu2014EffectsOO,
  title={Effects of oestrogen on long noncoding RNA expression in oestrogen receptor alpha-positive ovarian cancer cells},
  author={Junjun Qiu and Lechi Ye and Jingxin Ding and Weiwei Feng and Keqin Hua},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={2014},
  volume={141},
  pages={60-70}
}
Although oestrogen (E2) signalling has long been implicated in epithelial ovarian cancer (EOC) progression, the underlying mechanisms remain unknown. Long noncoding RNAs (lncRNAs) play a major role in cancer progression; therefore, our aim was to explore whether any lncRNA is regulated by E2 and plays some potential roles in the hormonal regulation of EOC progression. Here, we reported that E2 significantly dysregulated 115 lncRNAs (fold change ≥1.5, P<0.05) in E2 receptor (ER) alpha (ER… CONTINUE READING
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