Effects of ocular injury and administration of brain-derived neurotrophic factor on survival and regrowth of axotomized retinal ganglion cells.

@article{MansourRobaey1994EffectsOO,
  title={Effects of ocular injury and administration of brain-derived neurotrophic factor on survival and regrowth of axotomized retinal ganglion cells.},
  author={S Mansour-Robaey and David B. Clarke and Yan Cong Wang and Garth M. Bray and Albert J. Aguayo},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1994},
  volume={91 5},
  pages={1632-6}
}
Optic nerve transection in adult rats results in the death of approximately 50% of the axotomized retinal ganglion cells (RGCs) by 1 week and nearly 90% by 2 weeks after injury. The capacity of brain-derived neurotrophic factor (BDNF) to prevent this early, severe loss of RGCs was investigated in vivo by intravitreal injections of BDNF [5 micrograms in 5 microliters of bovine serum albumin/phosphate-buffered saline (BSA/PBS)] or vehicle (5 microliters of BSA/PBS). Using quantitative anatomical… CONTINUE READING
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