Effects of octreotide in acute hemorrhagic necrotizing pancreatitis in rats

@article{Wenger2007EffectsOO,
  title={Effects of octreotide in acute hemorrhagic necrotizing pancreatitis in rats},
  author={F. Wenger and M. Kilian and I. Heukamp and T. Foitzik and C. Jacobi and H. Guski and I. Schimke and Joachim Michael M{\"u}ller},
  journal={Journal of Gastroenterology and Hepatology},
  year={2007},
  volume={22}
}
  • F. Wenger, M. Kilian, +5 authors Joachim Michael Müller
  • Published 2007
  • Medicine
  • Journal of Gastroenterology and Hepatology
Background and Aim:  Octreotide is considered to reduce exocrine pancreatic secretion in acute hemorrhagic necrotizing pancreatitis decreasing pancreatic autodigestion. The aim of this study was to determine whether octreotide also has antioxidative effects in acute pancreatitis. Additionally time and dose of application were of interest. 
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TLDR
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References

SHOWING 1-10 OF 39 REFERENCES
Octreotide treatment of acute pancreatitis
AIM: To observe the effect of octreotide(Oct) in treatment of acute pancreatitis. METHODS: Forty-three patients with acute pancreatitis were randomly divided into 2 groups: 21 patients wereExpand
The Role of Octreotide and Somatostatin in Acute and Chronic Pancreatitis
TLDR
Treatment of other complications of the disease (pseudocyst formation, fistula and pancreatic ascites), with somatostatin or octreotide has given conflicting results, but in a prophylactic clinical setting the inhibition of exocrine pancreatic secretion reduces complications. Expand
Effect of the somatostatin analogue octreotide on experimental pancreatitis in rats.
TLDR
It is concluded that the somatostatin analogue octreotide has a beneficial effect in the treatment of experimental acute pancreatitis in rats. Expand
Prophylactic octreotide reduces the severity of histopathologic changes and hemodynamic shock in early taurodeoxycholate-induced experimental pancreatitis.
  • C. Chen, S. Wang, +5 authors S. Lee
  • Medicine
  • Proceedings of the National Science Council, Republic of China. Part B, Life sciences
  • 1999
TLDR
It is concluded that prophylactic octreotide improves pancreatic histopathology and hemodynamic shock in TDC-induced pancreatitis. Expand
Effects of delayed administration of octreotide in acute experimental pancreatitis.
TLDR
Octreotide had beneficial effects in acute experimental pancreatitis, and was more effective when started earlier, indicating that octreotide may have a role in the management of acute pancreatitis. Expand
Octreotide in the treatment of acute pancreatitis: results of a unicenter prospective trial with three different octreotide dosages.
TLDR
The results of this study are promising and must be validated in a controlled clinical trial with octreotide in a larger patient population. Expand
High dose octreotide in the management of acute pancreatitis.
TLDR
Although biochemical and physiologic changes between the two groups were not significantly different, a more pronounced decrease in serum amylase levels, improvements in pancreatic edema and earlier return to oral intake in the high dose-octreotide group suggest that octreotide may have a beneficial role in the management of acute pancreatitis. Expand
Continuous Intravenous Octreotide Treatment for Acute Experimental Pancreatitis
TLDR
Continuous intravenous octreotide infusion is a potentially efficacious therapeutic method for acute pancreatitis and had significant beneficial effects on histopathological damage and the biochemical alterations which are associated with acute Pancreatitis. Expand
A better model of acute pancreatitis for evaluating therapy.
TLDR
The authors conclude that combining minimal intraductal bile acid exposure with intravenous hyperstimulation produces homogeneous pancreatitis of intermediate severity that can be modulated at will and the model provides superior opportunity to study innovative therapy. Expand
A randomized, controlled trial of octreotide in the management of patients with acute pancreatitis
  • C. McKay, J. Baxter, C. Imrie
  • Medicine
  • International journal of pancreatology : official journal of the International Association of Pancreatology
  • 1997
TLDR
Octreotide was not found to be of benefit in the treatment of acute pancreatitis and there was no significant difference in the incidence of complications or mortality. Expand
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