Effects of obesity on severity of colitis and cytokine expression in mouse mesenteric fat. Potential role of adiponectin receptor 1.

@article{Sideri2015EffectsOO,
  title={Effects of obesity on severity of colitis and cytokine expression in mouse mesenteric fat. Potential role of adiponectin receptor 1.},
  author={Aristea Sideri and Dimitris Stavrakis and Collin Bowe and David Q Shih and Phillip R. Fleshner and Violeta Arsenescu and Razvan I. Arsenescu and Jerrold R Turner and Charalabos Pothoulakis and Iordanes Karagiannides},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2015},
  volume={308 7},
  pages={G591-604}
}
In inflammatory bowel disease (IBD), obesity is associated with worsening of the course of disease. Here, we examined the role of obesity in the development of colitis and studied mesenteric fat-epithelial cell interactions in patients with IBD. We combined the diet-induce obesity with the trinitrobenzene sulfonic acid (TNBS) colitis mouse model to create groups with obesity, colitis, and their combination. Changes in the mesenteric fat and intestine were assessed by histology, myeloperoxidase… CONTINUE READING
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