Effects of obesity and weight loss on the functional properties of early outgrowth endothelial progenitor cells.

@article{Heida2010EffectsOO,
  title={Effects of obesity and weight loss on the functional properties of early outgrowth endothelial progenitor cells.},
  author={N Heida and Jan-Peter M{\"u}ller and I-Fen Cheng and Maren Leifheit-Nestler and Vivien Faustin and Joachim Riggert and Gerd Hasenfuss and Stavros V. Konstantinides and Katrin Sch{\"a}fer},
  journal={Journal of the American College of Cardiology},
  year={2010},
  volume={55 4},
  pages={357-67}
}
OBJECTIVES The purpose of this study was to examine the impact of obesity and weight loss on the angiogenic and regenerative capacity of endothelial progenitor cells (EPCs). BACKGROUND EPCs participate in angiogenesis and tissue repair. Several cardiovascular risk factors are associated with EPC dysfunction. METHODS Early outgrowth EPCs were isolated from 49 obese (age 42 +/- 14 years; body mass index 42 +/- 7 kg/m(2)) normoglycemic participants in a professional weight reduction program… CONTINUE READING

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