Effects of obesity, diabetes and exercise on Fndc5 gene expression and irisin release in human skeletal muscle and adipose tissue: in vivo and in vitro studies.

@article{Kurdiov2014EffectsOO,
  title={Effects of obesity, diabetes and exercise on Fndc5 gene expression and irisin release in human skeletal muscle and adipose tissue: in vivo and in vitro studies.},
  author={Timea Kurdiov{\'a} and Miroslav Bal{\'a}{\vz} and Marek Vician and Denisa Maderova and Miroslav Vlcek and Ladislav Valkovi{\vc} and Miroslav Srbecky and Richard Imrich and Oľga Kyselovi{\vc}ov{\'a} and V{\'i}ťazoslav Belan and Ivan Jelok and Christian Wolfrum and Iwar Klime{\vs} and Martin Krss{\'a}k and Erika Zemkov{\'a} and Daniela Ga{\vs}per{\'i}kov{\'a} and Jozef Ukropec and Barbara Ukropcov{\'a}},
  journal={The Journal of physiology},
  year={2014},
  volume={592 5},
  pages={1091-107}
}
Irisin was identified as a myokine secreted by contracting skeletal muscle, possibly mediating some exercise health benefits via 'browning' of white adipose tissue. However, a controversy exists concerning irisin origin, regulation and function in humans. Thus, we have explored Fndc5 gene and irisin protein in two clinical studies: (i) a cross-sectional study (effects of type 2 diabetes (T2D) in drug-naive men) and (ii) an intervention study (exercise effects in sedentary, overweight/obese… CONTINUE READING
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A PGC1–α-dependent myokine that drives brown-fat-like development of white fat

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