Effects of nutrients and hormones on transcriptional and post-transcriptional regulation of acetyl-CoA carboxylase in rat liver.

@article{Katsurada1990EffectsON,
  title={Effects of nutrients and hormones on transcriptional and post-transcriptional regulation of acetyl-CoA carboxylase in rat liver.},
  author={Akihiko Katsurada and Nobuko Iritani and Hitomi Fukuda and Yoshihiro Matsumura and Natsumi Nishimoto and Tamio Noguchi and Toshio Tanaka},
  journal={European journal of biochemistry},
  year={1990},
  volume={190 2},
  pages={435-41}
}
The effects of nutrients and hormones on transcriptional and post-transcriptional regulation of acetyl-CoA carboxylase in rat liver were investigated following a cDNA cloning. After refeeding a carbohydrate/protein diet to fasted rats, the transcriptional rate was increased 2.5-fold in only 1 h. The mRNA concentration reached a maximal level of 9-12-fold increase in 8-16 h, and the enzyme induction increased 10-fold in 48 h. By a carbohydrate diet without protein, the transcriptional rate, mRNA… CONTINUE READING