Effects of novel small compounds targeting TrkB on neuronal cell survival and depression-like behavior.

Abstract

Brain-derived neurotrophic factor (BDNF) and its high affinity receptor tyrosine kinase receptor B (TrkB) are involved in neuronal survival, maintenance, differentiation and synaptic plasticity. Deficiency of BDNF was reported to be associated with psychological disorders such as depression. Hence we examined proliferative effect of 11 candidate TrkB… (More)
DOI: 10.1016/j.neuint.2016.04.017

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