Effects of noradrenaline on neuronal NOS2 expression and viability.

  title={Effects of noradrenaline on neuronal NOS2 expression and viability.},
  author={Jos{\'e} Luis Mu{\~n}oz Madrigal and Cinzia Dello Russo and Vitaliy Gavrilyuk and Douglas L Feinstein},
  journal={Antioxidants & redox signaling},
  volume={8 5-6},
The authors previously showed that conditioned media (CM) from activated microglia increased inducible nitric oxide synthase (NOS2) in cortical neurons. Here they examined the ability of noradrenaline (NA) to reduce neuronal NOS2 or cell death. Primary mouse cortical neurons were activated using CM from microglia incubated with lipopolysaccharide (LPS). Neuronal NOS2 was assessed by increases in nitrite accumulation, and increases in NOS2 mRNA levels and fluorescence of the NO-sensitive probe… CONTINUE READING

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