Effects of nor-binaltorphimine on butorphanol dependence.

  title={Effects of nor-binaltorphimine on butorphanol dependence.},
  author={S P Jaw and Masaharu Makimura and Beth Hoskins and Ing Kang Ho},
  journal={European journal of pharmacology},
  volume={239 1-3},
Butorphanol has been shown to act on mu-, delta-, and kappa-opioid receptors. However, the relative involvement of different opioid receptor subtypes in butorphanol dependence is not known. In the present study, nor-binaltorphimine, a long-acting non-peptide kappa-opioid receptor antagonist, was employed to mask central kappa-opioid receptors before and during the induction of butorphanol dependence in rats, so that the involvement of kappa-opioid receptors could be elucidated. The results… CONTINUE READING


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