Effects of nootropic drugs in a scopolamine-induced amnesia model in mice

@article{Verloes1988EffectsON,
  title={Effects of nootropic drugs in a scopolamine-induced amnesia model in mice},
  author={R. Verloes and A W Scotto and J M Gobert and Ernst W{\"u}lfert},
  journal={Psychopharmacology},
  year={1988},
  volume={95},
  pages={226-230}
}
Scopolamine (3 mg/kg IP) given before an acquisition trial, reduced the retention of a one-trial passive avoidance “step through” response in mice. A single administration of cholinergic agonists such as oxotremorine, BM-5, or arecoline, antagonized this amnesic effect of scopolamine. A significant anti-amnesic effect was also found with nootropic drugs such as piracetam and ucb L059, whereas ucb L060 (the enantiomer of ucb L059), oxiracetam and rolziracetam were shown to be ineffective… CONTINUE READING