Effects of nonsteroidal antiinflammatory drugs on renal function in patients with renal insufficiency and in cirrhotics.

@article{Brater1986EffectsON,
  title={Effects of nonsteroidal antiinflammatory drugs on renal function in patients with renal insufficiency and in cirrhotics.},
  author={Dr D. Craig Brater and Sarah A Anderson and D Brown-Cartwright and Robert Daniel Toto},
  journal={American journal of kidney diseases : the official journal of the National Kidney Foundation},
  year={1986},
  volume={8 5},
  pages={351-5}
}
We have assessed the effects of acute and chronic administration of etodolac, ketoprofen, and indomethacin on renal function in patients with mild to moderate chronic renal insufficiency (CRI). We studied 18 normal volunteers and 24 patients with CRI due to hypertension and/or diabetes mellitus with creatinine clearances between 19 and 83 mL/min/1.73 m2. Clearance studies were performed with the first dose of nonsteroidal antiinflammatory drug (NSAID) to compare acute effects of the agent with… CONTINUE READING