Effects of nonsteroidal anti-inflammatory drugs on amyloid-β pathology in mouse skeletal muscle

@article{Beckett2010EffectsON,
  title={Effects of nonsteroidal anti-inflammatory drugs on amyloid-β pathology in mouse skeletal muscle},
  author={Tina L. Beckett and Dana M. Niedowicz and Christa M. Studzinski and Adam M. Weidner and Michael P Murphy},
  journal={Neurobiology of Disease},
  year={2010},
  volume={39},
  pages={449-456}
}
Sporadic inclusion body myositis (sIBM) is a common age-related inflammatory myopathy characterized by the presence of intracellular inclusions that contain the amyloid-beta (Abeta) peptide, a derivative of the amyloid precursor protein (APP). Abeta is believed to cause Alzheimer's disease (AD), suggesting that a link may exist between the two diseases. If AD and sIBM are linked, then treatments that lower Abeta in brain may prove useful for sIBM. To test this hypothesis, transgenic mice that… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

Similar Papers

Loading similar papers…