Effects of nonlinear propagation, cavitation, and boiling in lesion formation by high intensity focused ultrasound in a gel phantom.

  title={Effects of nonlinear propagation, cavitation, and boiling in lesion formation by high intensity focused ultrasound in a gel phantom.},
  author={Vera A. Khokhlova and Michael R. Bailey and Justin A. Reed and Bryan W. Cunitz and Peter J. Kaczkowski and Lawrence A. Crum},
  journal={The Journal of the Acoustical Society of America},
  volume={119 3},
The importance of nonlinear acoustic wave propagation and ultrasound-induced cavitation in the acceleration of thermal lesion production by high intensity focused ultrasound was investigated experimentally and theoretically in a transparent protein-containing gel. A numerical model that accounted for nonlinear acoustic propagation was used to simulate experimental conditions. Various exposure regimes with equal total ultrasound energy but variable peak acoustic pressure were studied for single… 

Impact of cavitation on lesion formation induced by high intensity focused ultrasound

High intensity focused ultrasound (HIFU) has shown a great promise in noninvasive cancer therapy. The impact of acoustic cavitation on the lesion formation induced by HIFU is investigated both

Shock-induced heating and millisecond boiling in gels and tissue due to high intensity focused ultrasound.

Efficient Generation of Cavitation Bubbles in Gel Phantom by Ultrasound Exposure with Negative-Followed by Positive-Peak-Pressure-Emphasized Waves

Cavitation bubbles have much potential for emphasizing therapeutic treatments such as high-intensity focused ultrasound (HIFU) treatment, histotripsy, and sonodynamic therapy. Their highly efficient

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Simulation of high-intensity focused ultrasound lesions in presence of boiling

An equivalent model for the heat deposition pattern in the presence of boiling is proposed, enabling to efficiently simulate unitary pulses properties, including the sizes of the lesions, their morphology, the boiling onset time, and the influence of the boiled onset time on the lesions sizes.

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Models for how different types of cavitation activity can serve to accelerate tissue heating are presented, and results suggest that the bulk of the enhanced heating effect can be attributed to the absorption of broadband acoustic emissions generated by inertial cavitation.

Microbubble behavior in an ultrasound field for high intensity focused ultrasound therapy enhancement.

Numerical results show that localized heating is induced with increasing viscosity or shear elasticity, though it depends on the pressure amplitudes, and it was numerically confirmed that the localization of the microbubble distribution is important to obtain efficient localized heating.

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The results suggest that careful processing of the cavitation signals can serve as a proxy for measuring the heating contribution from inertial cavitation.

Study on cavitation behavior during high-intensity focused ultrasound exposure by using optical and ultrasonic imaging

Cavitation bubbles are known to enhance the heating effect of high-intensity focused ultrasound (HIFU). In our previous study, the use of a “triggered HIFU” sequence consisting of a high-intensity



Modeling of high-intensity focused ultrasound-induced lesions in the presence of cavitation bubbles

The classical "Bio Heat Transfer Equation (BHTE)" model is adapted to take into account the effects of oscillating microbubbles that occur naturally in the tissue during high-intensity focused ultrasound (HIFU) treatment and a better in-depth homogeneity of lesions is observed when the acoustic frequency of HIFU is increased.

Thermal effects of sawtooth waveform HIFU in tissue phantoms

Effect of acoustic nonlinearity of biological tissue results in ultrasound waveform distortion and, for high level of acoustic pressure, in formation of shock fronts. This effect may be strongly

Effect of acoustic nonlinearity on heating of biological tissue by high-intensity focused ultrasound

Effect of strong acoustic nonlinearity on the efficiency of heating of a biological tissue by high-intensity focused ultrasound in the modes of operation used in real clinical setups is studied. The

Physical mechanisms of the therapeutic effect of ultrasound (a review)

An improved understanding of the physical mechanisms of therapeutic ultrasound is essential to meet challenges and to further advance therapeutic ultrasound.