Effects of non-enzymatic glycation on cancellous bone fragility.

  title={Effects of non-enzymatic glycation on cancellous bone fragility.},
  author={Simon Y. Tang and U Zeenath and Deepak Vashishth},
  volume={40 4},
Post-translational modifications of collagen, such as non-enzymatic glycation (NEG), occur through the presence of extracellular sugars and cause the formation of advanced glycation end-products (AGEs). While AGEs have been shown to accumulate in a variety of collagenous human tissues and alter the tissues' functional behavior, the role of AGEs in modifying the mechanical properties of cancellous bone is not well understood. In this study, an in vitro ribosylation model was used to examine the… CONTINUE READING