Effects of nocturnal hemodialysis on melatonin rhythm and sleep-wake behavior: an uncontrolled trial.

@article{Koch2009EffectsON,
  title={Effects of nocturnal hemodialysis on melatonin rhythm and sleep-wake behavior: an uncontrolled trial.},
  author={Birgit C. P. Koch and E. Christiaan Hagen and J. Elsbeth Nagtegaal and Jan B S Boringa and Gerard Kerkhof and Piet Marten ter Wee},
  journal={American journal of kidney diseases : the official journal of the National Kidney Foundation},
  year={2009},
  volume={53 4},
  pages={658-64}
}
BACKGROUND End-stage renal disease and its treatment are associated with sleep disturbances such as deterioration of the circadian sleep-wake pattern. Melatonin rhythm, which has an important role in this pattern, is disturbed. The nocturnal melatonin surge is absent in this population. Whether nocturnal in-center hemodialysis changes melatonin and sleep-wake rhythms is unknown. STUDY DESIGN A nonrandomized uncontrolled trial. Patients served as their own controls. SETTING & PARTICIPANTS… CONTINUE READING
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