Effects of nitrofurans on adrenal cortical tissue in chickens.

  title={Effects of nitrofurans on adrenal cortical tissue in chickens.},
  author={A L Bartlet and Fazal Hameed Khan},
  journal={Journal of veterinary pharmacology and therapeutics},
  volume={13 2},
In chicken adrenal glands, aspartate transaminase (AST) activity is concentrated in the adrenal cortical cells. Administration of a bolus dose of furazolidone (200 mg/kg) to the birds produced a decrease in AST activity in the adrenal glands and a general disorganization in the ultrastructure of the adrenal cortical cells. Many adrenal cortical mitochondria appeared to be moribund, being swollen, without cristae or apparently empty. These effects preceded atrophy of the adrenal cortical tissue… CONTINUE READING


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