Effects of nitric oxide on ovulation and ovarian steroidogenesis and prostaglandin production in the rabbit.

@article{Yamauchi1997EffectsON,
  title={Effects of nitric oxide on ovulation and ovarian steroidogenesis and prostaglandin production in the rabbit.},
  author={Junji Yamauchi and Toshio Miyazaki and Shiho Iwasaki and Ikuko Kishi and Masako Kuroshima and Chuwa Tei and Yuichi Yoshimura},
  journal={Endocrinology},
  year={1997},
  volume={138 9},
  pages={3630-7}
}
Evidence supports the involvement of nitric oxide (NO) in ovarian physiology. The present study was undertaken to investigate the role of the NO/NO synthase (NOS) systems in ovulation, oocyte maturation, ovarian steroidogenesis, and PG production using in vitro perfused rabbit ovaries. The addition of the NOS inhibitors, aminoguanidine hemisulfate salt (AG) and N-omega-nitro-L-arginine methyl ester (L-NAME), to the perfusate inhibited the ovulation induced by hCG in a dose-dependent manner… CONTINUE READING

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