Effects of nitric oxide on matrix metalloproteinase-2 production by rheumatoid synovial cells.

Abstract

Nitric oxide (NO) is a multifunctional messenger molecule generated from L-arginine by a family of enzymes, including nitric oxide synthase (NOS). This study was performed to examine whether NO modulates the production of matrix metalloproteinases (MMPs), which degrade all components of extracellular matrix (ECM), in rheumatoid synovial cells. We… (More)

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Cite this paper

@article{Hirai2001EffectsON, title={Effects of nitric oxide on matrix metalloproteinase-2 production by rheumatoid synovial cells.}, author={Yasuo Hirai and Kiyoshi Migita and Susumu Honda and Yukitaka Ueki and Shinji Yamasaki and Shiro M Urayama and Makoto Kamachi and Atsushi Kawakami and Hiroyuki Ida and Masakazu Kita and Tetsuya Fukuda and K Shibatomi and Yoshiki Kawabe and Tetsuji Aoyagi and Katsumi Eguchi}, journal={Life sciences}, year={2001}, volume={68 8}, pages={913-20} }