Effects of nine synthetic putative metabolites of primaquine on activity of the hexose monophosphate shunt in intact human red blood cells in vitro.

@article{Jk1986EffectsON,
  title={Effects of nine synthetic putative metabolites of primaquine on activity of the hexose monophosphate shunt in intact human red blood cells in vitro.},
  author={Baird Jk and McCormick Gj and Canfield Cj},
  journal={Biochemical Pharmacology},
  year={1986},
  volume={35},
  pages={1099-1106}
}
  • Baird Jk, McCormick Gj, Canfield Cj
  • Published 1986
  • Chemistry
  • Biochemical Pharmacology
  • Suspensions of washed human red blood cells were treated with nine synthetic putative metabolic derivatives of primaquine (PQ'), and their individual effects on activity of the hexose monophosphate shunt (HMS) were quantitated by radiometric analysis of 14CO2 from [14C]glucose. The most potent HMS stimulant was 5-hydroxy-6-methoxy-8-aminoquinoline (5H6MQ), which caused 10-fold elevation of HMS activity at an estimated concentration of 0.004 mM. Ten millimolar primaquine (PQ) was required to… CONTINUE READING
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