Effects of nifedipine on myometrial activity and lower abdominal pain in women with primary dysmenorrhoea.

@article{Andersson1978EffectsON,
  title={Effects of nifedipine on myometrial activity and lower abdominal pain in women with primary dysmenorrhoea.},
  author={Karl-Erik Andersson and Ulf Ulmsten},
  journal={British journal of obstetrics and gynaecology},
  year={1978},
  volume={85 2},
  pages={142-8}
}
The effects of the calcium antagonist nifedipine on uterine activity and lower abdominal pain were studied during the first menstrual day in 10 women with severe primary dysmenorrhoea. Intrauterine pressure was recorded at three different levels by means of microtransducers. Nifedipine, 20 to 40 mg given orally, within 10 to 30 minutes effectively reduced the myometrial activity and relieved the pain. A moderate increase in heart rate, and a transient facial flushing were noted. In some… CONTINUE READING