Effects of nicotinic acid on poloxamer 407-induced hyperlipidemia.

  title={Effects of nicotinic acid on poloxamer 407-induced hyperlipidemia.},
  author={V J Nash and Thomas P. Johnston and Wally Palmer},
  volume={16 1},
We attempted to determine the mechanism(s) of poloxamer (P)-407-induced hyperlipidemia in rats by administering a lipid-lowering drug with a known mechanism of action. Five weight-matched animals were assigned to each of four treatment groups. Two groups received P-407 300 mg/ml and two received saline 1 ml. One of the P-407 and one of the saline groups were administered nicotinic acid 100 mg/kg by intraperitoneal injection at 6-96 hours after blood sampling. Blood samples were collected at 7… CONTINUE READING


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