Effects of nicotine on the nucleus accumbens and similarity to those of addictive drugs

  title={Effects of nicotine on the nucleus accumbens and similarity to those of addictive drugs},
  author={F. Pontieri and G. Tanda and F. Orzi and G. Chiara},
  • F. Pontieri, G. Tanda, +1 author G. Chiara
  • Published 1996
  • Medicine
  • Nature
  • THE question of whether nicotine, the neuroactive compound of tobacco, is addictive has been open to considerable scientific and public discussion. Although it can serve as a positive reinforcer in several animal species, including man, nicotine is thought to be a weak reinforcer in comparison with addictive drugs such as cocaine and heroin1,2, and has been argued to be habit forming but not addictive3,4. Here we report that intravenous nicotine in the rat, at doses known to maintain self… CONTINUE READING
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