Effects of nicotine on the nucleus accumbens and similarity to those of addictive drugs

  title={Effects of nicotine on the nucleus accumbens and similarity to those of addictive drugs},
  author={Francesco Ernesto Pontieri and Gianluigi Tanda and Francesco Orzi and Gaetano di Chiara},
THE question of whether nicotine, the neuroactive compound of tobacco, is addictive has been open to considerable scientific and public discussion. Although it can serve as a positive reinforcer in several animal species, including man, nicotine is thought to be a weak reinforcer in comparison with addictive drugs such as cocaine and heroin1,2, and has been argued to be habit forming but not addictive3,4. Here we report that intravenous nicotine in the rat, at doses known to maintain self… Expand
Nicotine and heroin augment cocaine-induced dopamine overflow in nucleus accumbens.
In vivo brain microdialysis findings support behavioral data suggesting that the reinforcing effects of cocaine and heroin are additive and predict that nicotine will enhance the reinforcing effect of cocaine. Expand
The putative role of extra-synaptic mesolimbic dopamine in the neurobiology of nicotine dependence
It is proposed that, at times when the plasma nicotine concentration is sufficiently high to cause desensitisation of the receptors, tobacco smoking is maintained by the conditioned reinforcers present in the tobacco smoke. Expand
Is dopamine important in nicotine dependence?
  • M. Shoaib
  • Biology, Medicine
  • Journal of Physiology-Paris
  • 1998
The discriminative stimulus effects of nicotine, despite showing some modification with dopaminergic compounds, appear not to be solely mediated via the mesolimbic dopamine system, and dissociation between stimulus properties may permit the development of more effective therapies in combating tobacco dependence. Expand
Functional correlates of nicotine administration: similarity with drugs of abuse
The results demonstrate that nicotine shares with highly addictive drugs a distinct neurochemical and functional consequence that contribute to the neurochemical definition of the addictive nature of nicotine. Expand
Baclofen antagonizes nicotine‐, cocaine‐, and morphine‐induced dopamine release in the nucleus accumbens of rat
The data are in line with previous reports demonstrating the ability of baclofen to modulate the mesolimbic DAergic transmission and indicate bacl ofen as a putative candidate in the pharmacotherapy of polydrug abuse. Expand
The role of mesoaccumbens dopamine in nicotine dependence.
  • D. Balfour
  • Psychology, Medicine
  • Current topics in behavioral neurosciences
  • 2015
There is abundant evidence that the dopamine (DA) neurons that project to the nucleus accumbens play a central role in neurobiological mechanisms underpinning drug dependence. This chapter considersExpand
The neuronal pathways mediating the behavioral and addictive properties of nicotine.
  • D. Balfour
  • Psychology, Medicine
  • Handbook of experimental pharmacology
  • 2009
The biological mechanisms that mediate the effects of cues and stimuli associated with the presentation of nicotine, which are thought to contribute significantly to the powerful addictive properties of tobacco smoke, are considered. Expand
Receptor systems participating in nicotine-specific effects
Comparisons of the effects of receptor-specific antagonists on the increase of dopamine induced by nicotine with that induced by cocaine in the nucleus accumbens in conscious rats indicate that there are differences in some of the receptors mediating the central effects of the two compounds examined, nicotine and cocaine, although each influences dopamine levels, and that theTwo compounds interact. Expand
Role of dopamine in the behavioural actions of nicotine related to addiction.
Experimental impairment of dopamine function by 6-hydroxydopamine lesions or by dopamine receptor antagonists shows that dopamine is involved in nicotine's discriminative stimulus properties,Expand
Nicotine activates and desensitizes midbrain dopamine neurons
It is shown that the same concentration of nicotine achieved by smokers activates and desensitizes multiple nicotinic receptors thereby regulating the activity of mesolimbic dopamine neurons, which could mediate the rewarding aspects of tobacco use. Expand


Regulation of Intravenous Nicotine Self-Administration — Dopamine Mechanisms
Data suggest that dopamine mechanisms, perhaps in the mesolimbic system, play a role in nicotine reinforcement, and that nicotine self-administration is a powerful reinforcer in this situation. Expand
A psychomotor stimulant theory of addiction.
A new attempt at a general theory of addiction is offered, based on the common denominator of the psychomotor stimulants---amphetamine, cocaine, and related drugs---rather than on thecommon denominators of the socalled depressant drugs~opiates, barbiturates, alcohol, and others. Expand
Drugs of abuse: anatomy, pharmacology and function of reward pathways.
  • G. Koob
  • Psychology, Medicine
  • Trends in pharmacological sciences
  • 1992
The results suggest that brain reward systems have a multidetermined neuropharmacological basis that may involve some common neuroanatomical elements. Expand
Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.
  • G. Di Chiara, A. Imperato
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1988
The effect of various drugs on the extracellular concentration of dopamine in two terminal dopaminergic areas, the nucleus accumbens septi (a limbic area) and the dorsal caudate nucleus (aExpand
Lack of tolerance to nicotine-induced dopamine release in the nucleus accumbens.
The failure to find evidence of tolerance is compatible with the hypothesis that the mesolimbic dopaminergic system is a substrate for the reinforcing properties of chronically administered nicotine. Expand
Psychopharmacology of Nicotine: Stimulus Effects and Receptor Mechanisms
The paradoxical status of the pharmacology of nicotinic mechanisms as a research problem has both stimulated and frustrated psychopharmacologists. The paradox is the dissonance between the practicalExpand
The role of dopamine in drug abuse viewed from the perspective of its role in motivation
Drugs of abuse share with conventional reinforcers the activation of specific neural pathways in the CNS that are the substrate of their motivational properties. Dopamine is recognized as theExpand
Intravenous cocaine, morphine, and amphetamine preferentially increase extracellular dopamine in the "shell" as compared with the "core" of the rat nucleus accumbens.
In vivo neurochemical evidence is provided for a functional compartmentation within the nucleus accumbens and for a preferential effect of psychostimulants and morphine in the shell of the nucleus Accumbens at doses known to sustain intravenous drug self-administration. Expand
Nicotine psychopharmacology : molecular, cellular, and behavioural aspects
Jerome H. Jaffe: Tobacco, smoking, and nicotine dependence Michael D.B. Swedburg, Jack E. Henningfield, & Steven R. Goldberg: Evidence of nicotine dependency from animal studies: self-administration,Expand
Psychostimulant drugs increase glucose utilization in the shell of the rat nucleus accumbens.
The results of the study show that, at these dosages, both drugs increase glucose utilization in the shell, but not in the core of NAc, which might reflect functional differences between the two portions ofNAc, probably relevant to the abuse liability of psychostimulants. Expand