Effects of nicotine on the nucleus accumbens and similarity to those of addictive drugs

@article{Pontieri1996EffectsON,
  title={Effects of nicotine on the nucleus accumbens and similarity to those of addictive drugs},
  author={Francesco Ernesto Pontieri and Gianluigi Tanda and Francesco Orzi and Gaetano di Chiara},
  journal={Nature},
  year={1996},
  volume={382},
  pages={255-257}
}
THE question of whether nicotine, the neuroactive compound of tobacco, is addictive has been open to considerable scientific and public discussion. Although it can serve as a positive reinforcer in several animal species, including man, nicotine is thought to be a weak reinforcer in comparison with addictive drugs such as cocaine and heroin1,2, and has been argued to be habit forming but not addictive3,4. Here we report that intravenous nicotine in the rat, at doses known to maintain self… Expand
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  • Psychology, Medicine
  • Current topics in behavioral neurosciences
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There is abundant evidence that the dopamine (DA) neurons that project to the nucleus accumbens play a central role in neurobiological mechanisms underpinning drug dependence. This chapter considersExpand
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  • Handbook of experimental pharmacology
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The biological mechanisms that mediate the effects of cues and stimuli associated with the presentation of nicotine, which are thought to contribute significantly to the powerful addictive properties of tobacco smoke, are considered. Expand
Receptor systems participating in nicotine-specific effects
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Role of dopamine in the behavioural actions of nicotine related to addiction.
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Nicotine activates and desensitizes midbrain dopamine neurons
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It is shown that the same concentration of nicotine achieved by smokers activates and desensitizes multiple nicotinic receptors thereby regulating the activity of mesolimbic dopamine neurons, which could mediate the rewarding aspects of tobacco use. Expand
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