Effects of nicotine on proliferation, cell cycle, and differentiation in immortalized and malignant oral keratinocytes.

@article{Lee2005EffectsON,
  title={Effects of nicotine on proliferation, cell cycle, and differentiation in immortalized and malignant oral keratinocytes.},
  author={H M Lee and Han-Young Guo and Sun-kyung Lee and Byung-Hun Jeon and C. Blattn{\'y} Jun and Suk Keun Lee and Myung-Hee Park and Eun-Cheol Kim},
  journal={Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology},
  year={2005},
  volume={34 7},
  pages={436-43}
}
BACKGROUND Numerous epidemiological studies have reported that tobacco smoking is a major risk factor for oral cancer, but relatively little is known about the effect of nicotine, a major product of cigarette smoking, on immortalized oral keratinocytes and cancer cells. METHODS We investigated the effects of nicotine on the growth and differentiation of immortalized human oral keratinocytes (IHOK), primary oral cancer cells (HN4), metastatic oral cancer cells (HN12), and human skin… CONTINUE READING

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