Effects of nicotine on cultured cells suggest that it can influence the formation and resorption of bone.

@article{Yuhara1999EffectsON,
  title={Effects of nicotine on cultured cells suggest that it can influence the formation and resorption of bone.},
  author={Senji Yuhara and Shimpei Kasagi and Akane Inoue and Eri Otsuka and Sho-ichi Hirose and Hiromi Hagiwara},
  journal={European journal of pharmacology},
  year={1999},
  volume={383 3},
  pages={387-93}
}
The acute effects of nicotine [1-methyl-2-(3-pyridyl)pyrrolidine] on the formation and resorption of bone were examined in cultures of clonal rat calvarial osteogenic cells (ROB-C26) and clonal mouse calvarial preosteoblastic cells (MC3T3-E1), as well as in osteoclast-like cells formed during coculture of mouse bone marrow cells and clonal stromal cells from mouse bone marrow, ST2 cells, at concentrations that occur in the saliva of smokeless tobacco users. Nicotine stimulated the rate of… CONTINUE READING

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