Corpus ID: 23572605

Effects of nicorandil and its congeners on musculature and vasculature of the dog trachea in situ.

@article{Maruyama1982EffectsON,
  title={Effects of nicorandil and its congeners on musculature and vasculature of the dog trachea in situ.},
  author={M. Maruyama and K. Satoh and N. Taira},
  journal={Archives internationales de pharmacodynamie et de therapie},
  year={1982},
  volume={258 2},
  pages={
          260-6
        }
}
In anesthetized dogs, the tracheal vascular bed in situ was perfused with arterial blood through the cannulated cranial thyroid arteries. The effects of nicorandil, a coronary vasodilator, and its congeners (SG-212, GS-209 and SG-103; in which the nitroxy group of nicorandil was substituted for other groups) on the tracheal musculature and vasculature were examined. All drugs were injected intra-arterially. Nicorandil (10-300 micrograms), SG-212 (100 micrograms-3 mg), SG-209 (100 micrograms-3… Expand
The relaxant action of nicorandil in guinea‐pig isolated trachealis
Relationship between relaxation and cyclic GMP formation caused by nicorandil in canine mesenteric artery
  • M. Endoh, N. Taira
  • Chemistry, Medicine
  • Naunyn-Schmiedeberg's Archives of Pharmacology
  • 2004
Nicorandil inhibits degranulation and TNF-α release from RBL-2H3 cells