Effects of nickel chloride on lactating rats and their suckling pups, and the transfer of nickel through rat milk.

@article{Dostal1989EffectsON,
  title={Effects of nickel chloride on lactating rats and their suckling pups, and the transfer of nickel through rat milk.},
  author={Lori A. Dostal and Sidney M. Hopfer and Siu Mee Lin and F. William Sunderman},
  journal={Toxicology and applied pharmacology},
  year={1989},
  volume={101 2},
  pages={220-31}
}
The excretion of nickel into rat milk following subcutaneous (sc) doses of nickel chloride (NiCl2) and the effects on the lactating rat and her suckling pups were determined. Plasma and milk Ni concentrations increased in a dose-dependent manner 4 hr after single doses of 0, 10, 50, or 100 mumol NiCl2/kg to lactating rats, giving milk/plasma Ni ratios of 0.02. Peak plasma Ni concentrations were reached 4 hr after injection, while milk Ni increased until 12 hr and remained elevated at 24 hr… CONTINUE READING