Effects of neutral endopeptidase inhibition in the rat remnant kidney model.

@article{JandeleitDahm1998EffectsON,
  title={Effects of neutral endopeptidase inhibition in the rat remnant kidney model.},
  author={Karen Jandeleit-Dahm and Louise M Burrell and Masayuki Kanazawa and David Casley and Bruce Jackson and C. I. Johnston},
  journal={Kidney & blood pressure research},
  year={1998},
  volume={21 6},
  pages={419-24}
}
The orally active neutral metalloendopeptidase (NEP) inhibitor SCH34826 was given by oral gavage in a dose of 90 mg/kg twice daily for 3 days to rats with subtotal nephrectomy (n = 7) and effects were compared to a placebo group receiving phosphate buffer (n = 5). Inhibition of neutral endopeptidase in the remnant kidney was measured by in vitro… CONTINUE READING