Effects of neurotropic agents with a selectivity for alpha-adrenoceptors on nitrile-induced dyskinetic syndrome in mice.

Abstract

Allylnitrile, crotononitrile and 2-pentenenitrile induce this behavioral syndrome, which includes persistent random circling, head twitching and backward running. The effects of neurotropic agents, with a selectivity for the alpha 1 or alpha 2 adrenoceptor, were examined on the nitrile-induced behavioral abnormalities. The alpha 1 agonist phenylephrine, the alpha 2 agonist clonidine and the alpha 1 antagonist prazosin, inhibited the behavioral syndrome induced by each nitrile, while the alpha 2 antagonist yohimbine had no effect. These results suggest that the noradrenergic system may be involved in the manifestation of the syndrome. Furthermore, a tonic noradrenergic influence on subcortical systems may be required for the syndrome to occur.

Cite this paper

@article{Tanii1990EffectsON, title={Effects of neurotropic agents with a selectivity for alpha-adrenoceptors on nitrile-induced dyskinetic syndrome in mice.}, author={Hideji Tanii and M Hayashi and Ken Hashimoto}, journal={Pharmacology, biochemistry, and behavior}, year={1990}, volume={36 2}, pages={317-20} }