Effects of neurotoxic destruction of descending noradrenergic pathways on cannabinoid antinociception in models of acute and tonic nociception.

@article{Gutirrez2003EffectsON,
  title={Effects of neurotoxic destruction of descending noradrenergic pathways on cannabinoid antinociception in models of acute and tonic nociception.},
  author={T V{\'a}zquez Guti{\'e}rrez and Andrea Gail Nackley and Mark H. Neely and Kimberly G. Freeman and G. L. Edwards and Andrea G Hohmann},
  journal={Brain research},
  year={2003},
  volume={987 2},
  pages={176-85}
}
The effects of neurotoxic destruction of catecholaminergic projections to the spinal cord on cannabinoid antinociception were examined in models of acute and tonic nociception. High performance liquid chromatography was used to quantify monoamine levels in sham-operated and lesioned rats. Intrathecal administration of the catecholamine neurotoxin 6-hydroxydopamine (6-OHDA) induced a selective depletion of norepinephrine (by approximately 85% of control) in rat lumbar spinal cord without… CONTINUE READING
16 Extracted Citations
0 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 16 extracted citations

Similar Papers

Loading similar papers…