Effects of neurotensin receptor antagonism on latent inhibition in Sprague-Dawley rats

@article{Binder2002EffectsON,
  title={Effects of neurotensin receptor antagonism on latent inhibition in Sprague-Dawley rats},
  author={Elisabeth B. Binder and Robin E. Gross and Charles B. Nemeroff and Clinton D. Kilts},
  journal={Psychopharmacology},
  year={2002},
  volume={161},
  pages={288-295}
}
Abstract Rationale. It has been postulated that the tridecapeptide neurotensin (NT) functions as an endogenous antipsychotic peptide. A critical test of this hypothesis would be to determine if NT is involved in the expression of latent inhibition (LI), a psychophysiological and pharmacological model of schizophrenia. Objective. This report describes the effects of disrupting NT neurotransmission by systemic administration of the NT receptor antagonists SR48692 and SR142948A on the acquisition… CONTINUE READING

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