Effects of neurotensin and bombesin on the secretory and proliferative activity of regenerating rat adrenal cortex.

  title={Effects of neurotensin and bombesin on the secretory and proliferative activity of regenerating rat adrenal cortex.},
  author={Anna Hoch{\'o}l and Anna Markowska and Virgilio Meneghelli and N. Jedrzejczak and Mariola Majchrzak and Mariusz Nowak and Gastone Giovanni Nussdorfer and Ludwik K. Malendowicz},
  journal={Histology and histopathology},
  volume={14 4},
Neurotensin (NT) and bombesin (BM)-like peptides are known to be involved in the regulation of the rat hypothalamo-pituitary-adrenal axis. By using selective NT- and BM-receptor antagonists (NT-A and BM-A, respectively) we investigated whether endogenous NT and BM-like peptides play a role in the control of rat adrenal secretion and growth during enucleation-induced regeneration. At day 5 of regeneration, NT-A did not affect the plasma concentrations of aldosteronc (PAC) and corticosterone (PBC… Expand
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The evidence suggests that the greatest differences between the functions of the zones are between the glomerulosa and the fasciculata, and the biosynthesis of aldosterone in the rat certainly requires reinterpretation. Expand
Expression of selected genes involved in steroidogenesis in the course of enucleation-induced rat adrenal regeneration.
Data from the current study strongly suggest the role of Fabp6, Lipe and Soat1 in supplying substrates of regenerating adrenocortical cells for steroid synthesis and indicates that during the first days of adrenal regeneration, intense synthesis of cholesterol may occur, which is then followed by its conversion into cholesteryl esters. Expand
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Role of Neurotransmitters and Neuropeptides in the Regulation of the Adrenal Cortex


Effects of bombesin and neuromedin-B on the proliferative activity of the rat adrenal cortex.
Findings indicate that BM and NMB enhance the proliferative activity of rat adrenocortical cells acting via different receptors or different mediators. Expand
Different effects of neurotensin and neuromedin-N on the proliferative activity of rat adrenal cortex.
Findings indicate that NT and NMN enhance rat adrenal growth in vivo acting via different mediators. Expand
Proliferogenic effect of neurotensin (NT) and neuromedin-N (NMN) on the rat adrenal cortex: Evidence that angiotensin-II mediates the effect of NMN, but not of NT
The data suggest that ANG-II mediates the proliferogenic effect of NMN, but not that of NT, and that NMN injection induced a burst of adrenocortical cell proliferation within 12 h, and this effect was prevented by SAR. Expand
Comparison of the effects of neurotensin and vasopressin on the adrenal cortex of dexamethasone-suppressed rats
The findings indicate that the mechanism underlying the aldosterone secretagogue action of AVP does not require, unlike that of NT, the presence of ACTH, and could suggest the possibility that in vivo NT acts on the rat adrenal cortex via AVP. Expand
Effect of neurotensin and substance P on adrenal cortex regeneration
It was found that SP stimulated both the proliferation and steroidogenesis on the eighth day after operation, and neurotensin did not evoke any significant changes either in the proliferation ratio or corticosterone production of regenerating adrenal cortex. Expand
Effects of bombesin on the morphology and function of the rat adrenal cortex: comparison of the acute and chronic responses.
It is suggested that the conspicuous stimulation of adrenocortical-cell proliferation evoked by BM infusion may be responsible for the apparent lack of effect of this treatment on B secretion. Expand
Comparison of the effects of neurotensin and ACTH on the pituitary-adrenocortical axis of dexamethasone-suppressed rats
The conclusion is drawn that NT modulates the function of the rat pituitary-adrenocortical axis, by simultaneously stimulating hypophyseal ACTH release and inhibiting steroidogenesis at the adrenal level. Expand
Effects of neurotensin on the pituitary-adrenocortical axis of intact and dexamethasone-suppressed rats.
Findings suggest that NT exerts a direct inhibitory effect on B production by rat adrenals, while it is able to enhance ACTH secretion and consequently adrenal growth, and indicate that NT evokes a striking, and at present unexplained dissociation between structure and function in the adrenal cortex of Dx-suppressed rats. Expand
The role of neuromedin B in the regulation of rat pituitary-adrenocortical function.
It is suggested that NMB specifically stimulates aldosterone secretion, and that endogenous NMB or NMB-like peptides exert a tonic stimulating action on the growth of zona fasciculata cells. Expand
Studies on the preventive action of neurotensin on dexamethasone-induced adrenocortical atrophy.
It is indicated that NT, like ACTH, prevents Dx-induced adrenocortical atrophy, and that this effect does not depend, as does that ofACTH, upon the stimulation of proliferation of adrenoc Cortical cells. Expand