Effects of neurosteroids on kainate-induced seizures, neurotoxicity and lethality in mice.

@article{Lekiewicz1997EffectsON,
  title={Effects of neurosteroids on kainate-induced seizures, neurotoxicity and lethality in mice.},
  author={Monika Leśkiewicz and Bogusława Budziszewska and Lucylla Jaworska-Feil and Władysław Lasoń},
  journal={Polish journal of pharmacology},
  year={1997},
  volume={49 6},
  pages={
          411-7
        }
}
In the present study we examined effects of some neurosteroids on the kainate-induced seizures, lethality and neurotoxicity in mice. We found that 5 alpha-pregnan-3 alpha-ol-20-one (allopregnanolone; 10 and 20 mg/kg) markedly elevated CD50 for kainate-induced convulsions, whereas 5 beta-pregnan-3 alpha-ol-20-one, 5 alpha-pregnan-3 alpha-ol-11,20-dione, 5 alpha-androstan-3 alpha-ol-17-one, dehydroepiandrosterone sulfate, pregnenolone sulfate and aminosteroid (U-107) were ineffective in that test… CONTINUE READING