Effects of neuropeptide Y deficiency on hypothalamic agouti-related protein expression and responsiveness to melanocortin analogues.

@article{Marsh1999EffectsON,
  title={Effects of neuropeptide Y deficiency on hypothalamic agouti-related protein expression and responsiveness to melanocortin analogues.},
  author={Donald J. Marsh and Grant I. Miura and K A Yagaloff and Michael J. Schwartz and Gregory S Barsh and Richard D Palmiter},
  journal={Brain research},
  year={1999},
  volume={848 1-2},
  pages={66-77}
}
Central administration of neuropeptide Y (NPY) potently induces feeding and its abundance in the hypothalamus increases when energy stores fall. Consequently, NPY is considered to be a physiological effector of feeding behavior. Surprisingly, NPY-deficient (NPY-/-) mice feed and grow normally with ad libitum access to food and manifest a normal hyperphagic response after fasting, suggesting that other feeding effectors may compensate for the lack of NPY. Agouti-related protein (AgRP), a… CONTINUE READING

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