Effects of neuromuscular-blocking drugs in rats in vivo: direct measurements in the diaphragm and tibialis anterior muscle.

@article{Itoh2004EffectsON,
  title={Effects of neuromuscular-blocking drugs in rats in vivo: direct measurements in the diaphragm and tibialis anterior muscle.},
  author={Hironori Itoh and Kunitaka Shibata and Tetsuro Matsumoto and Shunichi Nitta and Masaaki Nishi and Takuya Kobayashi and Kaoru Yamamoto},
  journal={Acta anaesthesiologica Scandinavica},
  year={2004},
  volume={48 7},
  pages={
          903-8
        }
}
BACKGROUND Effects of neuromuscular-blocking drugs are often investigated in rodents using both the diaphragm in vitro and the tibialis anterior muscle in vivo. Differences in the properties of these muscles cannot be neglected. We evaluated the neuromuscular effects of drugs on the rat diaphragm in vivo in comparison with the tibialis anterior muscle, directly measuring twitch tension with a force transducer. METHODS Respectively using sternotomy and an approach via the gluteal space… CONTINUE READING