Effects of net charge and the number of positively charged residues on the biological activity of amphipathic alpha-helical cationic antimicrobial peptides.

@article{Jiang2008EffectsON,
  title={Effects of net charge and the number of positively charged residues on the biological activity of amphipathic alpha-helical cationic antimicrobial peptides.},
  author={Ziqing Jiang and Adriana I. Vasil and John D. F. Hale and Robert E. Hancock and Michael L. Vasil and Robert S. Hodges},
  journal={Advances in experimental medicine and biology},
  year={2008},
  volume={611},
  pages={561-2}
}
In our previous study, we utilized a 26-residue amphipathic alpha-helical antimicrobial peptide L-V13K (Chen et al., Antimicrob Agents Chemother 2007, 51, 1398-1406) as the framework to study the effects of peptide hydrophobicity on the mechanism of its antimicrobial action. In this study, we explored the effects of net charge and the number of positively charged residues on the hydrophilic/polar face of L-V13K on its biological activity (antimicrobial and hemolytic) and biophysical properties… CONTINUE READING